Health Disease

Systemic lupus erythematosus (SLE). Symptoms and Treatment.

what is SLE?

Systemic lupus erythematosus the type of lupus (auto immune disease), is the mild to life threatening disease or more accurately a condition that remain for the rest of the life. The actual cause of SLE is still unknown. The treatment of which is directed to manage and improve the sign symptoms of the condition. SLE have the young onset that is it is most often seen in people of age from 15 to 48 years. this condition has no cure discovered yet hence preventive measures should be taken and when diagnosed it should be managed. The only preventive measure for SLE is to avoid exposure to direct sunlight as UV rays can cause SLE. If one already has SLE, depression, drugs such as Septra and Bactrim, garlic, sprouts and high cholesterol diet should be avoided as they can complicate symptoms in. The most affected organs by SLE include Heart, blood vessels, joints, skin, lungs, brain, and kidney.

TESTS

Series of Urine tests and CBC (complete blood count) are conducted to diagnose SLE as low level of complement indicates the presence of lupus. Whereas ANA is regarded as confirmatory test for SLE.

Sign and Symptoms

the associated signs and symptoms of systemic lupus erythematosus the appear on the onset of SLE (early signs) are butterfly rash (classic symptom), fever, fatigue, articular (joint) pain appearance of Cutaneous rashes (on skin), Fever, hair loss, GIT disturbance, Dry mouth, intestinal inflammation, liver enlargement, pulmonary diseases, pain when breathing deeply, sensitivity two sunlight, swelling in hands feet or around eye and kidney inflammation. SLE and other lupus diseases are major risk factors for developing Different types of cancer the most common of which is lymphoma (cancer of lymphoid organs). Systemic lupus erythematosus is not a contagious disease that means it cannot be transmitted through contacts.

SLE

Complications

SLE have tendency to produce multiple complications throughout the body. the most common of which are pleurisy, pleural effusion, pulmonary hypertension, indecision lung diseases, Skin scarring, joint deformity, kidney failure, stroke, heart attack, pregnancy complications, cataract and avascular necrosis. The most common and serious manifestation of SLE is lupus nephritis. whereas the risk factors for SLE can genetic or environmental. Environmental risk factors include active or passive smoking, high UV index i.e., prolonged exposure to sunlight and exposure to potentially damaging chemicals. Certain drugs such as anti-seizures, capoten, methyldopa may also trigger the symptoms of SLE. The biggest complication of lupus is kidney disease which get worse over the time and may result in kidney failure.

Treatment

no known cure or SLE is yet discovered hence the management of SLE includes immunosuppressant, (to lessen the symptoms due to overactivity of immune system i.e., autoimmunity) steroids, antimalarial drugs and Anifrolumab (latest drug). according to you new research daratumumab (monoclonal antibody) can be used successfully for the treatment of systemic lupus erythematosus.in condition such as SLE Rheumatologists should be consulted. And if kidneys are affected too, urologist should be consulted, first dialysis and kidney transplant later are the only options left.

Pathogenesis

SLE is Generally related to loss of self-tolerance of immune system due to activation of B and T, that leads to the production of antibodies resulting in tissue Injury. lupus glomerulonephritis is a prototype of SLE (Autoimmune diseases). The mechanism of kidney disease due to underlying SLE is still unknown.

SLE

Research

Researchers are being conducted to discover pathogenesis, causes and effects of SLE. Epidemiologists have calculated the prevalence of SLE to be 43.7% globally. The incidence of SLE IS 5.14 per 100,000 people. Studies have showed that SLE can cause kidney damage, but it is not the only cause of kidney failure. LRA (Lupus research alliance) Is conducting different research to find out the cause treatment of SLE. Many phases of research studies have already been completed. Lets hope we soon will find the effective treatment foe SLE.

Conclusion

WE Successfully have concluded that SLE is a condition diabetes which can effect a person at any and it can be managed. Most of the patients live normal lifespan with appropriate treatment. the associated signs and symptoms should be considered seriously to prevent the advancement in disease and progression of signs. As SLE can progressed into life threatening conditions.

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